Studies on Antitumor Agents. I. Antitumor Activity of 5 (4)-Amino-4 (5)-imidazolecarboxamide Analogs
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منابع مشابه
The effect of 4-amino-5-imidazolecarboxamide on the toxicity of 8-azaguanine.
The guanine analog, 8-azaguanine, has been shown to possess carcinostatic properties against transplantable tumors in experimental animals (7, 8). I t was believed that the compound inhibited the proliferation of tumor cells by acting as an antimetabolite in the biosynthesis of nucleic acid purines of the neoplastic tissue. To elucidate the mechanism of action of the drug, the possibility of an...
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[15N]Aspartate and 5-amino-4-imidazolecarboxamide riboside (AICAriboside) were used to evaluate the contribution of the purine nucleotide cycle to ammonia production in renal tubules isolated from control and chronically acidotic rats. Addition of 1 mM AICAriboside to incubation medium containing 2.5 mM [15N] aspartate significantly stimulated production of 15NH3 and 15N in the 6-amino group of...
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The compound 4-amino-5-imidazolecarboxamide first was isolated by Stetten and Fox (1) from the medium of Escherichia coli which had been inhibited by sulfonamides. It was identified by Shive et al. (2) and recognized as a possible precursor of nucleic acid purines. Schulman et al. (3) showed that pigeon liver homogenates can convert 4-amino-5-imidazolecarboxamide to hypoxanthine, whereas the in...
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Phortress is a novel, potent, and selective experimental antitumor agent. Its mechanism of action involves induction of CYP1A1-catalyzed biotransformation of 2-(4-amino-3-methylphenyl)-5-fluorobenzothiazole (5F 203) to generate electrophilic species, which covalently bind to DNA, exacting lethal damage to sensitive tumor cells, in vitro and in vivo. Herein, we investigate the effects of DNA add...
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The compound 4-amino-5-imidazolecarboxamide first was isolated by Stetten and Fox (1) from the medium of Escherichia coli which had been inhibited by sulfonamides. It was identified by Shive et al. (2) and recognized as a possible precursor of nucleic acid purines. Schulman et al. (3) showed that pigeon liver homogenates can convert 4-amino-5-imidazolecarboxamide to hypoxanthine, whereas the in...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 1968
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.16.2080